The Serine/Threonine Phosphatase Inhibitor Calyculin A Induces Rapid Degradation of IκBβ
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چکیده
منابع مشابه
Stimulation of Suicidal Erythrocyte Death by Phosphatase Inhibitor Calyculin A.
BACKGROUND/AIMS The serine/threonine protein phosphatase 1 and 2a inhibitor Calyculin A may trigger suicidal death or apoptosis of tumor cells. Similar to apoptosis of nucleated cells, erythrocytes may enter eryptosis, the suicidal erythrocyte death characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface. Triggers of eryptosi...
متن کاملInhibition of a K+ conductance by the phosphatase inhibitor calyculin A in rat distal colon.
Basal membrane permeability of epithelial cells from the lower third and the middle of rat colonic crypts is dominated by a K+ conductance as shown by ion replacement experiments. Calyculin A, an inhibitor of protein phosphatases, induced a depolarization of these cells. The depolarization was concomitant with an inhibition of membrane current. The current inhibited by calyculin A had a reversa...
متن کاملActivity-dependent enhancement of synaptic transmission in hippocampal slices treated with the phosphatase inhibitor calyculin A.
The role of protein phosphatases in regulating synaptic transmission in the CA1 region of the hippocampus was examined using slices pretreated with calyculin A, a specific inhibitor of protein phosphatases 1 and 2A. Stimulation of afferents at 1 Hz (but not 0.1 Hz) for periods of 5-10 min caused a long-lasting enhancement of synaptic transmission. The increase in synaptic responses was not due ...
متن کاملThe Phosphatase Inhibitor Calyculin-A Impairs Clot Retraction, Platelet Activation, and Thrombin Generation
The aim of this study was to investigate the effect of the serine/threonine protein phosphatase inhibitor, calyculin-A (CLA), on clot formation and on the procoagulant activity of human platelets. Platelet-rich plasma (PRP) samples were preincubated with buffer or CLA and subsequently platelets were activated by the protease-activated receptor 1 (PAR-1) activator, thrombin receptor activating p...
متن کاملPhosphatase Inhibitor Calyculin A Activates TRPC2 Channels in Thyroid FRTL-5 Cells
We have previously shown that rat thyroid FRTL-5 cells express a calcium entry pathway regulated by a phosphatase. The nature of the calcium entry pathway is presently unknown. We have also shown that FRTL-5 cells express only the TRPC2 channel of the TRPC family of cation channels. In the present investigation we show, using pharmacological inhibitors, the measurement of sodium and calcium ent...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1997
ISSN: 0021-9258
DOI: 10.1074/jbc.272.9.5409